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Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular pertinence, muscle strength, body composition and physical fitness, according to a new study. The findings appear in the April way out of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (http://www.interscience.wiley.com/).

About one-in-four U.S. adults suffers from NAFLD, which describes a range of liver disease characterized through excessive fat in the liver. NAFLD is the most common effect of abnormal liver enzymes, and the leading reason for referrals to hepatology clinics. It is considered by many to be a manifestation of the metabolic syndrome which is inferior prevalent among physically fit people, but that feeble is known about the relationship between fitness and NAFLD severity.

To address this verbal contest, researchers led by Joanne Krasnoff of the University of California San Francisco recruited 37 adult patients by a spectrum of NAFLD severity as measured by means of liver biopsy. Across the spectrum of NAFLD severity, patients had suboptimal cardiorespiratory fitness, muscle strength, body composition and physical activity participation. More than 97 percent had a body obese percentage that set them at increased risk for morbidity and human race and less than 20 percent currently met recommended guidelines with regard to physical activity.

The study did demonstrate lower cardiorespiratory fitness in subjects with increasing NAFLD severity. “This stimulant finding raised the question of a cause-or-effect phenomenon - does cardiorespiratory fitness attenuate NAFLD or does increasing NAFLD severity result in a inflect in cardiorespiratory aptness?” the authors ask.

“Despite our study limitations,” the authors conclude, “we believe the objective demonstration of low cardiorespiratory fitness and muscle strength with a high incidence of obesity illustrates the potential clinical relevance of these measures both before and after interventions.” Moreover, the verdict that specific measures of NAFLD severity may be associated with cardiorespiratory fitness and past natural activity raises the possibility of a defined curative role for prevention and exercise intervention.

Future studies should include a randomized controlled trial of exercise training that can reveal its direct effects attached NAFLD histopathology, they suggest. “In the meantime, it would appear rational and prudent for healthcare providers to praise exercise training to improve health-related fitness as every integral role in the feel interested of patients with NAFLD,” they conclude. This work was conducted as some ancillary study of the NAFLD Clinical study Network, a national research consortium funded by the National Institutes of Health.

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Article adapted by Medical News Today from original press release.
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Article: “Health-Related Fitness and Physical Activity in Patients with Nonalcoholic Fatty Liver Disease.” Krasnoff, Joanne; Painter, Patricia; Wallace, Janet; Bass, Nathan; Merriman, Raphael. Hepatology; April 2008; 10.1002/hep.22137 ; Published online March 2008.

Source: Sean Wagner
Blackwell Publishing Ltd.

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This entry was posted on Saturday, March 29th, 2008 at 12:32 am and is filed under Uncategorized. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.