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Several strains of the bird flu virus that raged across southern China were blocked from entering Thailand and Vietnam, UC Irvine researchers have discovered.

This first-ever statistical analysis of influenza A H5N1’s genetic diversity helps scientists better understand how the virus migrates and could, in the futurity, help health officials determine whether efforts to thwart its spread were successful.

“Some countries appear more exposed to bird flu invasion than others. Learning that is a good step in discovering which social and ecological factors excite, or, on the other participation, hamper the virus’ spread,” said Robert G. Wallace, a postdoctoral researcher and lead author of the study.

The results be in sight online Feb. 27 in the journal PLoS ONE.

Since its emergence in 1996, H5N1 has only sporadically been passed from birds to humans. Although only about 350 human cases of this influenza have been recorded worldwide, its high mortality rate raises concerns that if the virus mutates in of that kind a way that humans can pass it on, a deadly flu pandemic may result. More than 60 percent of humans who take the virus die from it.

In this study, Wallace and Walter M. Fitch, professor of ecology and evolutionary biology at UCI, analyzed nearly 500 publicly available genetic sequences of proteins form in a mould on the surface of the influenza virus. These sequences originally were collected from 28 Eurasian and African localities through 2006.

The study also showed that H5N1 strains circulating in Indonesia, Japan, Thailand and Vietnam shared the most evolutionary narrative with H5N1 circulating in several provinces in southern China. The provinces, Guangdong, Fujian and Hong Kong, are engaged in intensive international trade, including poultry. Previous study has concluded the poultry trade is a key mechanism for the spread of the H5N1 virus.

The researchers suggest that health officials trying to block new strains of the virus from spreading could use the methods employed in this study to determine whether interventions are working.

“You can think of it as a type of evolutionary forensics,” Wallace said. “When a bomb explodes, investigators can determine in what manner many charges went off and the brilliance and direction of the blast, all from the resulting damage without company. Here we can determine the way H5N1 has circulation and evolved by the resulting viral diversity.”

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Article adapted by Medical News Today from original press release.
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The National Institutes of Health funded the ponder.

About the University of California, Irvine: The University of California, Irvine is a top-ranked university dedicated to research, scholarship and community service. Founded in 1965, UCI is among the fastest-growing University of California campuses, with more than 27,000 undergraduate and graduate students, and nearly 2,000 adroitness members. The third-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3.6 billion.

Source: Jennifer Fitzenberger
University of California - Irvine

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